NAD+ is a critical coenzyme involved in energy production, DNA repair, and metabolic signaling. With age, NAD+ levels drop significantly-reducing mitochondrial efficiency and cellular resilience.
Betaine (trimethylglycine) acts as a methyl donor, playing a vital role in epigenetic regulation, detoxification, and maintaining balanced homocysteine levels. Methylation is fundamental to genetic expression, neurotransmitter production, and healthy aging.
By combining NAD+ with Betaine, this formula simultaneously supports mitochondrial energy output and optimal methylation—two foundational pillars of cellular health and longevity. This pairing also helps prevent methyl group depletion, which may occur with long-term NAD+ or niacin use.